Conversely, DNA chains within repressed chromatin architecture would manifest decreased responsiveness to invading RNA molecules, slow kinetics of DNA strand displacement, and decreased likelihood of acquisition of a PSDS of DNA double helix (Lee J, Hwang M, Landon PB, Lal R, Glinsky GV, in preparation).
In contrast, cells differentiated from macroadenoma-derived PASC2 manifested different responsiveness to hypothalamic hormone stimulation and hormone production properties.
Agonist ligands such as morphine that do not promote desensitization/endocytosis/resensitization of the MOR, have been shown to facilitate homeostatic adaptive responses in signal transduction that manifest as reduced responsiveness to the presence of opioid ligands at the cellular level, and as antinociceptive tolerance at the behavioral level (for review see [21]).
Ethical theorists and theologians of the day held, variously, that moral good and evil are discovered: (a) by reason in some of its uses (Hobbes, Locke, Clarke), (b) by divine revelation (Filmer), (c) by conscience or reflection on one's (other) impulses (Butler), or (d) by a moral sense: an emotional responsiveness manifesting itself in approval or disapproval (Shaftesbury, Hutcheson).
No significant increase in response to PRV was detected in grooming, cage crossing, or rearing in any treatment group or genetic background throughout the observation period, suggesting that the role of mast cells in pelvic pain is not due to generalized alterations in behavior that might be manifested as enhanced responsiveness to pelvic tactile stimuli.
As noted above, devices intended for continuous hemodynamic monitoring are required not only to provide acceptable estimates of CO and SV, but are also expected to manifest appropriate precision and responsiveness during times of changing hemodynamic performance.
Insofar as one is rational, one is disposed to respond appropriately to one's evidence: at any given time, one's views accurately reflect the character of one's evidence at that time, and one's views manifest a characteristic sensitivity or responsiveness to changes in one's evidence through time.
Recently, Uemura et al. [ 40] showed that the sensitivity of the Arabidopsis mutant sfr4 to freezing was due to its low sugar content, as manifested by loss of osmotic responsiveness.
Therefore, temporally sparse BOS-evoked firing and enhanced BOS selectivity, manifested as an absence of suprathreshold responsiveness to non-BOS stimuli, emerge in HVC.
Defects in insulin responsiveness, as for example manifested in obese subjects, contribute to the development of type 2 diabetes [2].
