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Furthermore, while key cellular phenotypes are conserved they manifest in distinct behavioural dysfunction.
Incomplete understanding of the specific etiologic pathways that manifest in distinct phenotypes has important implications for the translation of research into effective treatment and clinical management [ 16].
These differences highlight the fact that common cellular dysfunction across species may manifest in distinct behavioural phenotypes and may result from species-specific differences associated with ethologically relevant tasks (25).
In sum, not only is the recurrence risk of ASD higher in siblings than nonsiblings, but also there appears to be an increasingly heightened risk as a function of genetic relatedness and the extent of environmental similarity that may manifest in distinct neural, cognitive, and socioemotional profiles that typify ASD [ 48].
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First, since we know that the pathophysiology of invasive breast cancer differs with age [ 1– 4], perhaps this disease difference manifests in distinct mammographic appearance that allows better prediction in older versus younger women [ 23, 24].
The biodistribution of NPs is determined by body's biological barriers that manifest in several distinct ways.
Data from these two lines of research (i.e., genetic, neurocognitive studies) to date suggest that antisocial children with callous-unemotional traits are genetically more vulnerable to antisocial behaviour than their antisocial peers and that this genetic vulnerability may manifest in a distinct neurocognitive signature.
Age-related changes in fibers expressing various myosin light chain isoforms were previously described for MYL1, MYL2 and TNNT3 [ 15, 17, 20]; however, these changes were manifested differentially in distinct muscles.
To determine tissue-specific effects of LTRs, we asked whether a set of genes with transcription start sites within 10 kb downstream of an LTR (LTR-associated genes), manifest a distinct gene expression pattern in a tissue a pattern that differs from the expression pattern of these genes in other tissues.
These data suggest that the two separable functions of MglA, that is stimulation of motility and stimulation of reversals, are manifested in these two distinct activities, establishment of polarity of some motility proteins and regulation of their dynamic localization.
Infantile haemangiomas are vascular tumours, rather than malformations, as they exhibit a distinct life cycle: manifest in infancy with initial rapid growth and proliferation, followed by involution in early childhood.
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