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Most of these ESFT cases manifest defects in the maintenance of genomic stability with subsequent DNA copy number alterations.
Although IGT has been defined as a 2-h glucose of 140 199 mg/dL during an oral glucose tolerance test (OGTT), obese adolescents with 2-h plasma glucose 120 139 mg/dL already manifest defects in insulin secretion and action that are indistinguishable from those seen in adolescents with a 2-h glucose ≥140 mg/dL (7, 8).
Similar(58)
Code 2: clinically manifest defect, loss of tooth structure over less than 50% of the tooth surface.
Code 3: clinically manifest defect, loss of tooth structure over more than 50% of the tooth surface.
Interruption of Crb staining in some transverse connective branches manifested defects in the tracheal system already at stage 13.
Similarly, the NGT offspring manifested defects in muscle glucose transport and phosphorylation that were similar to those in lean and obese type 2 diabetic subjects (Fig. A7).
Hypertensive cardiovascular disease may also become manifest through defects in the vessels supplying the brain, leading to stroke.
It remains to be investigated whether a delay in pancreas regeneration could lead to manifest pancreas defects in the context of chronic organ damage.
In conclusion, obese adolescents who progress to IGT manifest primary defects in β-cell function.
CONCLUSIONS Obese adolescents who progress to IGT may manifest primary defects in β-cell function.
Thus, the TFIIB mutant derivatives R66E and S65A manifest their defects in supporting transcription at distinct events in the transcription sequence.
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