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The authors themselves discuss that the reliability of the diagnosis, reported by the "patients" themselves, is to be interpreted with caution, as it cannot be differed between a suspected case and a manifest case.
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We hypothesize that the higher frequency of arachnoid cysts corresponds to our selection of clinically more manifest cases of ADPKD, namely patients with PKD1 mutation.
On basis of clinical and genetic results MR imaging is a sensitive intra vitam tool to support the diagnosis of CA in manifest cases.
However, through screening late manifesting cases would also be detected.
Being prepared was mentioned as an advantage for the later manifesting cases.
Some interviewees valued screening in later manifesting cases as well, while stressing the need for adequate support of pre-symptomatic patients and their families.
In later manifesting cases most notably the timing of treatment and the psychological burden for the patient-in-waiting and the family were seen as major drawbacks.
Disadvantages included treatment costs and uncertainties about its effect, the timing of treatment in later manifesting cases, the psychological burden for the patient-in-waiting and the family.
A decreasing incidence of clinically manifested cases can be ascribed either to the increase in antibody levels in the community or to a change in the intrinsic virulence of the virus.
Advantages for both classic infantile and later manifesting cases included health gain, avoiding a diagnostic quest, having a reproductive choice in future pregnancies, and the ability to gain more knowledge about the disease and treatment.
While the number of smokers in high-death rate countries such as Denmark and the UK have fallen substantially since the 1970s, the long-term effects of historically high rates continue to manifest in cases of lung cancer and COPD today, the ERS said.
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