Surviving animals manifest numerous alterations, including important malformations in the trachea and the axial skeleton (ribs, sternum, tail), and defects in the neural tube closure giving rise to spina bifida phenotypes [7].
The observations that manipulations of crz neuronal physiology manifest as alterations in lifespan and other behavioral and physiological parameters during heterotypic stresses suggest a general contribution of crz neurons to stress responses.
Cancer cells manifest metabolic alterations that distinguish them from cells in normal tissues, which could be exploited for anticancer therapy.
Köberle (1968) suggested that neuron loss in the chronic phase of Chagas' disease is a continuous process lasting decades and that functional disturbances, i.e. discomfort of patients related to impaired gut motility, precede manifest macroscopic alterations, e.g. megacolon.
Chromosomal instability, which may manifest as alterations in chromosome number (aneuploidy) or inter- or intra-chromosomal rearrangement, is thought to arise early in tumourigenesis but increases with tumour progression (for a review, see [32]).
The increase in the kidney/body weight ratio observed by us in the present) and previous study [ 28] in the SMV-intoxicated rats may indicate that V accumulated sufficiently in the kidney to manifest significant alterations in the size of this organ.
These findings in human individuals support the view that some nicotine-dependent subjects may become addicted as a means of self-medication [ 29], explaining the fact that tobacco use is more prevalent and intense in human populations that manifest cognitive alterations [ 22].
At 200 μM the primary root growth was totally inhibited but the plants continued their growth manifesting different alterations in root development.
In contrast, IPF cells manifested large alterations in the ribosome recruitment pattern.
Our previous studies showed that binge-pattern ethanol (EtOH) treatment during pubertal development negatively dysregulated the responsiveness of the hypothalamo-pituitary-adrenal (HPA) axis, as manifested by alterations in corticotrophin-releasing hormone (CRH), arginine vasopressin (AVP), and corticosterone (CORT) during this time period.
