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▪ Manifest abnormalities on fundus photography in either of the eyes.
Human colorectal cancer cells that exhibit CIN do not have alterations in the MMR genes whereas cells with defective MMR mechanism are near diploid and do not manifest abnormalities associated with CIN [ 27].
Second, they manifest abnormalities in the highly restricted area of the hypothalamic satiety center and thus exhibit pathological features similar to those of some other mouse models of obesity, such as ob/ob and db/db mice, in which the hypothalamic leptin circuit is impaired [ 28, 29].
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HVD are a complex group of genetic disorders manifesting abnormalities of the vitreous and retina, affecting approximately 1 in 3000 people [41].
In some patients, the hormonal deficiencies may present as a part of a syndrome with patients manifesting abnormalities in structures that share a common embryological origin with the pituitary gland [ 29– 31].
For example, a significant number of individuals with ASD manifest epileptiform abnormalities on electroencephalograph (EEG) despite a lack of clinical seizures, and many of these epileptiform abnormalities do not meet criteria for electrographic seizures [ 4].
Up to 50 70% patients with muscular dystrophy manifest cardiac abnormalities, although it is clinically significant in only 10% of these patients [6].
However, in terms of attentional facilitation of cortical processing, we found that fallers manifest specific abnormalities in the sensory/perceptual processing of targets in the left visual field.
Moreover, very low birth weight premature infants manifest cerebellar abnormalities [6].
Impaired repolarization reserve does not necessarily lead to clinically manifest repolarization abnormalities on the ECG but makes the heart more susceptible to arrhythmia development [37] [39].
Wild baboons feeding on human waste foods manifest metabolic abnormalities consistent with human obesity and the cardiometabolic syndrome [ 13, 14].
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