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The last mania was not your run-of-the-mill speculative excess.
No association was found between manic severity and functioning, consistent with the literature (Rosa et al. 2010), and mania was not associated with social disadvantage.
We also found that although most of the BISS symptom domains (anxiety, irritability, depression, and psychosis) were associated with social disadvantage, mania was not (Table 2).
Somewhat different conclusions were drawn from the twin study of McGuffin et al. (2003), who reported a substantial genetic correlation between mania and depression (0.65), but found that 71%% of the variance for mania was not shared with depression.
Many modern scholars feel that the mania was not as extraordinary as Mackay described and argue that not enough price data are available to prove that a tulip bulb bubble actually occurred.
A few participants thought that the patient with mania was not ill but was exhibiting God's power or backsliding, faith healing was therefore mentioned as the appropriate treatment.
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In another way, his persecution mania wasn't entirely unfounded.
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The mechanism responsible for the therapeutic efficacy of lithium for the treatment of mania is not yet clear.
Dr. Victor Reus, a professor of psychiatry at the University of California, San Francisco, said dysphoric mania is not uncommon in patients with bipolar disorder, a vast majority of whom never turn to violence.
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