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Close monitoring of clonal and organ response is mandatory to guide therapy changes and duration.
Imaging is mandatory to guide management and to document disease progression.
Assessing the severity of AECOPD is mandatory to guide decisions of orientation as well as intensity of monitoring treatment and follow-up during and after the acute episode.
Blood cultures are mandatory to guide antimicrobial drug management.
As the successful antibiotic treatment of many bacterial intestinal infections requires knowledge of local resistance patterns (e.g. extent of fluoroquinolone-resistant Campylobacter strains), stool culture techniques remain mandatory to guide therapeutic interventions.
The list of targeted therapies is rapidly expanding, and molecular tests are already mandatory to guide treatment decisions for patients with metastatic colorectal carcinomas with EGFR antibodies [ 1, 2], lung carcinomas with EGFR inhibitors [ 3] and metastatic melanomas with BRAF inhibitors [ 4].
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The mandatory reporting scheme provides important data to guide the implementation of preventive measures.
A1 Bipartisan Alliance on Climate Senators John McCain, Republican of Arizona, and Joseph I. Lieberman, Democrat of Connecticut, joined forces to warn that the nation's isolation from a global warming pact could hurt business as well as the environment and said they wanted to guide the nation toward mandatory limits on greenhouse gases.
Histopathologic examinations remain the gold standard for establishing a glioma tumor grade; these examinations are mandatory at initial diagnosis to assess patient prognosis and to guide clinical and therapeutic management.
Careful assessment of thromboembolic risk to guide therapeutic decision making should be considered mandatory in subjects with a large extent of wall asynergy, even in those with no previous evidence of LV thrombosis.
It is mandatory to perform microbiologic investigation once the abscess is drained to guide further therapy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com