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From an engineering and architecture perspective it is mandatory to design cities taking into account energy and water issues to achieve high living and sustainability standards.
To support efficient content production and consumption on scale of TeraBytes or PetaBytes, it is mandatory to design decentralized content indexing algorithm to enable access and search over large-scale database.
In parallel to the numerous experimental studies designed to address these issues, initial clinical trials are underway or in preparation and it is mandatory to design and conduct them in a careful manner so as to ultimately know whether cellular transplantation holds its promise as a means of improving the outcomes of patients with heart failure.
In this framework, a robust estimation of direct (climate induced) and indirect (anthropogenically induced) effects of climate change is mandatory to design mitigation measures, especially in those regions of the planet where the groundwater equilibrium is strongly perturbed by exploitations for irrigation purposes.
It is mandatory to design a randomized controlled trial aimed at identifying pathophysiologically sound interventions targeting the relationship that we identify.
Consequently, in order to assess the real effect of low doses on CVD, it is mandatory to design long-term trials which include a sufficient number of patients.
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Reflections and experiences about management rules are a mandatory prerequisites to design processes for collective management.
Moreover, in the current era of multidisciplinary treatment of GIST, an appropriate classification is mandatory to properly design clinical trials and plan stage-adapted treatment.
Of course, as underlined by Tanenbaum [5], it is mandatory to explicitly design a communication protocol to ensure that consumers and producers can both use the shared data.
Obtaining a bright and low emittance electron beam directly from the photocathode is mandatory in order to design high performance free electron lasers (FELs).
An exhaustive knowledge of the topographic anatomy of this area is the mandatory in order to design an appropriate surgical strategy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com