A lipid survey should be mandatory before initiation of capecitabine or other 5-FU prodrugs.
Baseline studies including hormonal (thyroid, IGF-1) and metabolic measurements (glucose, insulin, and lipid profile) are mandatory before initiation of GH treatment.
It has been suggested that a strong SD sequence, though not mandatory in translation initiation, may compensate for a weak start codon and counteract mRNA secondary structures that hinder access to the start codon [ 9, 10].
The 5′UTR is of particular importance as it is structured in four domains building the internal ribosome entry site (IRES), a structure that is mandatory for proper initiation of HCV RNA translation (Niepmann, 2013).
Consequently, address verification before treatment initiation becomes mandatory for successful patient retrieval [10].
Altogether these data identify lipophagy of retinyl esters as a mandatory driver of the initiation and perpetuation of the activated phenotype of liver fibrogenic cells.
In 1996, soon after the initiation of the mandatory ethnicity data collection in secondary care, Pringle and Rothera showed ethnicity data collection to be feasible as well as acceptable to patients and staff in the primary care setting [ 20].
Given the severity and potential irreversibility of these symptoms, a quick and accurate diagnosis as well as an early initiation of treatment is mandatory.
For the maturation, however, cellular crosstalk at the initiation stage would be mandatory.
Two consecutive viral load measurements within 5 to 12 months after initiation of first line therapy were mandatory for inclusion into the analysis of treatment success.
Once a diagnosis of NTM disease has been reached, the initiation of therapy is not always mandatory.
