Sentence examples for mandatory for normal from inspiring English sources

It derives from the proepicardium that gives rise to the vasculature and interstitial cells of the heart during embryogenesis, a process that is mandatory for normal development [1], [2], [3], [4].

This might be due to a lack of IL-2, since NF-κB activation is mandatory for normal IL-2 production [43], [46], [47], [51], [55], [61], [62], [69], or due to a defect in IL-2R signaling converging in STAT5 activation [33].

While microglial function is beneficial and mandatory for normal CNS functioning, unregulated overactivation of microglia causes damage to neurons.

Proper E/I balance control is mandatory for normal cortical function; alterations in this balance can cause circuit dysfunction and disease.

A balance between these events is mandatory for normal mitochondrial and neuronal function, and emerging evidence indicates that mitochondria undergo extensive fission at an early stage during programmed cell death in several neurodegenerative diseases.

In sperm, ROS can cause potential damage to plasma membrane and DNA integrity, motility, and overall semen quality [ 2, 4, 5]; therefore, scavenging excess ROS is mandatory for normal spermatogenesis and fertilization.

Hence, SLP65 is a genuine signal integrator which is as mandatory as Syk for normal B lymphopoiesis and humoral immunity (Jumaa et al, 1999; Minegishi et al, 1999; Pappu et al, 1999; Hayashi et al, 2000; Xu et al, 2000).

Graduates from all tracks are liable for mandatory service (3 years for normal track students and CPIRD, and 12 years for ODOD), with a financial penalty of US$13,0000 for non-adherence by normal track and CPIRD graduates, and five times higher (US$65,0000) for ODOD graduates.

The reality is that the speed limit is a guide for normal conditions (and mandatory maximum), and does not account for less safe driving conditions.

Even when effective antimicrobial treatment is administered, administration of hydrocortisone at a regimen restoring normal secretion is mandatory for survival.

The presence of cerumen is normal and is mandatory for a physiological movement of microorganisms or foreign substances from the deep ear canal towards its external opening [ 7, 8].