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The persistent occurrence of aPL was the serological hallmark of APS and was defined as a mandatory classification criterion [26].
Regarding the term "deterioration" the Advocate General Jääskinen recommended a strict interpretation of the WFD with reference to a substance or quality component, without affecting a mandatory classification change [188].
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The harmonized classifications are the minimum mandatory classifications listed in Annex VI of the CLP regulation.
Identification of chromosomal abnormalities is mandatory for classification of acute myeloid leukemia (AML), and the abnormalities have to be determined quickly, to allow patient enrollment in multicenter protocols and/or for selecting therapeutic strategies.
However, such evidence was not mandatory for classification as positive control due to the acknowledged lack of pediatric-specific studies [ 30].
This demonstrates that RA with reduced molecular markers of inflammation can still be separated from osteoarthritis and that incorporation of such RA patients in the selection process of candidate genes is mandatory for correct classification.
The jobs classification as mandatory or optional is based on the m i and k i values of each task.
Moreover, in the current era of multidisciplinary treatment of GIST, an appropriate classification is mandatory to properly design clinical trials and plan stage-adapted treatment.
The MAC model is called mandatory [1], because the classification of "subjects" and "objects" is performed automatically by the system, without the intervention of users who theoretically cannot change these rating levels.
An agreement, between the three reviewers was mandatory for the final classification of studies.
Examples of clinically evident tophi are provided in figure 2. Serum urate was considered a mandatory element of the classification criteria scoring system (ie, the score cannot be computed without a serum urate value).
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