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The reforms they set in motion included the adoption of controlled clinical trials as the ultimate arbiters of therapeutic efficacy, the passage of the Kefauver-Harris amendments mandating proof of drug efficacy via well-controlled studies, and the empowering of the Food and Drug Administration to remove inefficacious drugs from the market.
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The U.S. Food and Drug Administration recently mandated proof of CV safety as a major requirement for the approval of new hypoglycemic drugs (32).
On the other hand, advances in certifying and marking cut diamonds, along with new laws in many countries that mandate proof of origin to discourage "blood diamonds" from countries with civil conflict, have made it harder to fence the most valuable polished stones, says Chaim Even-Zohar, an industry analyst based in Israel.
Supporters hailed the congressionally mandated study as proof the program works.
The fact that they chose to defend the Obamacare employer mandate is proof that the principle at the heart of this fight -- the extent of the executive branch's discretion to implement and enforce laws -- isn't what's animating Republicans.
Trees on these sites, which Don Blankenship and Massey proudly offer up with the West Virginia Department of Environmental Protection (an agency dedicated to the exact opposite of its mandate) as proof of their good intentions, grow a few feet in height at best and perish.
The law mandates a tamper-proof card that would become the only acceptable form of identification for federal purposes, such as boarding a commercial airliner or entering a federal building.
The industry only recently imposed rules, taking effect in 2017, mandating that shipowners carry insurance or show other proof that they can cover the costs of sailors marooned in port, as well as seafarers' death and long-term disability entitlements.
The new rules include stricter residency requirements for non-citizens, requiring team managers to have more detailed paperwork documenting their players' eligibility and mandating that more authoritative birth records be presented as proof of age.
Laws mandating that "credible" accusations must be reported to the police or child welfare authorities leave leeway for educators to remain silent, allowing them to claim insufficient proof.
Relieved of carrying heavy gear (which these days includes bear-proof canisters mandated by the National Park Service), hikers can enjoy the scenery by day and avoid pitching camp at night.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com