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Nonetheless, several drawbacks to TIL-based therapy, such as the need for surgery to obtain tumor tissue, the long time and high costs required to develop sufficient numbers of TIL, mandates the development of alternative or complementary cell-based approaches.
Developing programs or interventions to address HIV-related disability mandates the development of a measurement instrument.
The emergence and worldwide spread of multidrug-resistant strains of MTB mandates the development of more effective preventive and therapeutic tools [ 4].
This mandates the development of patient centred measurement tools that are able to balance the requirement of capturing TCAM specific effects, as well as maintaining optimal psychometric properties.
The EU Paediatric Regulation (EC 1901/2006) mandates the development of new medicinal products in children from birth to 18 years where there is a therapeutic need.
As these examples suggest, climate change impacts often can be addressed within existing legislative frameworks.> Each management system mandates the development of a management plan.
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The first is that the government has mandated the development of interoperable networks, where radios developed by different manufacturers and used by different organizations, will all be able to communicate with one another.
Alarmed by a federal study finding that 80percentt of child seats were being installed incorrectly, officials in the Transportation Department mandated the development of the Latch system in 1999.
That report also mandated the development of "gender-neutral physical standards" so that women could be evaluated head-to-head with their male colleagues.
And unlike the old days of regulation, state governments cannot mandate the development of excess generating capacity for independent producers, or the use of a varied mix of energy sources, instead relying on the marketplace to anticipate power needs and fuel supplies.
Long-duration manned space missions mandate the development of a sustainable life support system and effective countermeasures against damaging space radiation.
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