Dose reductions in TMZ were mandated in the event of grade IV haematological toxicity, grade III toxicity lasting 7 or more days or any grade III or IV nonhaematological toxicity.
Dose reductions in temozolomide were mandated in the event of grade 4 haematological toxicity, grade 3 toxicity lasting 7 or more days or any grade 3 or 4 non-haematological toxicity.
However, several months into the trial the DSMB reversed its decision and mandated the collection and reporting of all adverse events, including mild events.
Pablo Larraín's masterpiece film, NO! starring Gael Garcia Bernal, depicts events leading up to Chile's plebiscite to extend Gen Pinochet's mandate, the event that ultimately brought an end to Pinochet's violent regime.
There is also frustration that the governing bodies for eventing have not mandated the safety improvements they identified after another cluster of deaths nine years ago.
Arabic was mandated the official language, however.
Mr Alexander said the Lib Dems would look to see which party had the strongest mandate in the event of a hung parliament.
The term 'haemovigilance' was probably first used in France in 1991, and set into law by 1993 mandating the reporting of all adverse events in recipients.
Earlier this month, their efforts paid off: Republican Gov. Doug Ducey signed into law a bill mandating that in the event of a divorce, the spouse who "intends to allow the embryos to develop to birth" gets to keep them.
To better understand the extent of the GI distress, we chose to use different definitions of diarrhoea as the outcome measure and this mandated time to event analyses (Cox proportional hazards regression).
When reflection is mandated and evaluated, the events are not necessarily those that matter because important issues of clinical and ethical uncertainty that expose the doctor's vulnerability are less likely to be explored.
