Of note, both studies mandated modifications in the ruxolitinib dose in response to thrombocytopenia or neutropenia; in general, patients randomized to 20 mg and 15 mg twice daily were titrated down to 15 mg and 10 mg twice daily, respectively.
This would count strongly against them, or would mandate their modification to avoid this possibility.
Even as lenders have initiated a historic campaign to help delinquent borrowers avoid foreclosure, some in Congress continue to hold out judicially mandated loan modifications as the panacea for the housing crisis.
Addressing observations from previous sessions and incorporating them into subsequent sessions is effective in modifying curriculum in an incremental way rather than mandating major modifications (Kelley et al., 2010).
As policymakers search for solutions to the burgeoning problem of an indebted generation of college graduates, some lawmakers are zeroing in on mandating loan modification schemes or allowing more troubled student borrowers to discharge their unpayable debts in bankruptcy.
Proper adaptation of the questionnaire to the experience of Greek patients mandated slight modification of three questions.
Pilot testing was used as cognitive debriefing and adaptation of the questionnaire to the experience of Serbian patients mandated slight modification of only two questions.
Proper adaptation of the instrument to the Greek norms mandated slight modification of some items and a thorough revision of the translation process that had already been performed by previous investigators.
The court has been presented by plaintiffs with a proposed form of final judgment that would mandate both conduct modification and structural reorganization by the defendant when fully implemented.
While the development of more severe toxicities led to a dose delay or dose reduction, the development of individual grade 1 toxicities alone did not mandate any dose modification.
The Commission wishes to highlight some of Parliament's changes to its Rules of Procedure, in particular those relating to the proposed hearings in case of the appointment of a new Commissioner during the Commission's mandate or modifications in the portfolio of serving Commissioners, as well as those relating to a possible conflict of interest of a Commissioner.
