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Moreover, our approach will help in the identification and evaluation of new prognostic markers for the management of EOC.
Biomarkers to predict the chemotherapeutic response have clinical significance in the management of EOC patients (Kupryjanczyk et al, 2003; de Graeff et al, 2008).
The distinct molecular features of OCCC and serous ovarian cancer serve to emphasise the need to develop subtype-specific therapeutic approaches in the management of EOC.
The identification of a new cancer biomarker, in addition to common clinicopathological risk factors to select patients with good or bad outcome, will assist the follow-up management of EOC after surgery.
Given that the current guidelines for the management of EOC should be individualized according to the patient status, gynecologists must balance the risk of rapid metastases against the costs and adverse effects that accompany aggressive interventions.
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7 Current reports indicate a 20% response rate with contemporary agents, 6 emphasizing an absolute need for the development of innovative and effective therapeutic strategies for the management of advanced EOC.
Carboplatin remains a first-line agent in the management of epithelial ovarian cancer (EOC).
In the last decades, management of epithelial ovarian cancer (EOC) has been based on the staging system of the International Federation of Gynecology and Obstetrics (FIGO) and the evaluation of histological features of tumors [ 2].
In the last decades, management of epithelial ovarian cancer (EOC) has been based on the staging system of the International Federation of Gynecology and Obstetrics (FIGO), and different classifications have been proposed for EOC that take account of grade of differentiation, histological subtype, and clinical features.
Projecting this to the well-established fact that in advanced stages, tumour residual disease is the most significant prognostic factor for survival and that optimal tumour debulking to microscopic residuals is regarded as the cornerstone of therapeutic management in EOC, one could surmise that p53 status has a significant impact on overall prognosis even in advanced stage disease.
Molecular imaging by immuno-PET may possibly bridge this gap to achieve a timely detection of EOC for better disease management.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com