From an animal management perspective, mouse weaning took place at 21 days of life when the pups are separated into individual cages.
The authors wish to thank Hong Zhong and Andre Burey for their management of mouse colonies.
However, the interest in this livestock species is hampered by many challenges including diseases, inadequate nutrition, poor management practices, mice cannibalism on the pups, and predation by dogs and cats [ 5].
We also thank Dr. Rabinarayan Mishra and Keith Daniels for the helpful discussions and excellent technical assistance and Erin Cloherty for expert mouse management.
We are indebted to Maribel Muñoz for excellent mouse management, to Marta Cañamero and the Comparative Pathology Unit, and to Ramon Diaz-Uriarte for his help with statistical analyses.
The overall effectiveness of our approach as a tool for the routine management of GM mouse lines, was demonstrated by cryopreserving and recovering 735 GM lines maintained on twelve genetic backgrounds, including 527 GM lines maintained on the C57BL/6J background.
We thank Pamela W. M. Kleikers for her support in transgenic mouse management and supply.
A.R.B., G.J., J.E.C., J.K.E., R.B., and S.W. all aided in the phenotyping, breeding, and management of the mouse colonies.
The MRB, in addition to being a content-management system for mouse online resources and databases, aims to become an intermediary link between resources for the mouse community.
Although substantial work is needed to realize these opportunities for rodent management and particularly mice and rats, it is proposed that a syntheses of the knowledge gained so far could produce the essence of a push pull strategy for control.
