Initial management (doses and modalities of norepinephrine and fluid resuscitation) did not seem to be involved either.
The need for reassurance regarding self-management dosing decisions has also been observed in diabetes self-management.
Toxicity management by dose reduction and/or dose delay facilitated drug compliance.
However, few patients with an edema AE required management with dose modification (temporary dose interruption, 4 patients on bosutinib, and 1 patient on imatinib), and no patient in either arm required dose reduction or permanent discontinuation of treatment because of edema.
The last but not least problem is with antibiotics, especially during the acute phase of sepsis, as the management of dosing is very difficult during RRT and is probably better to favor continuous methods than intermittent ones.
The chapters on positioning, monitoring, airway management, drug dosing, ventilatory strategies, comorbidities, and post-operative care all include information that would be extremely relevant to the practice of both anesthetists and intensivists.
For instance, a systematic review found that computerized clinical decision support systems improved practitioner performance, leading to improved diagnosis, preventive care, disease management, drug dosing, or drug prescribing [ 14].
While the proposed treatment algorithm is based on the current knowledge and experience gained to date, further research will establish the best management strategy, dosing frequency and timing of injection and monitoring.
Garg et al [ 1] reviewed 100 randomised and non-randomised studies of CDSSs across a broad range of clinical targets including diagnosis, prevention, disease management, drug dosing and drug prescribing while the Kawamoto et al [ 2] review was restricted to randomised controlled trials (RCTs) but assessed the impact of both electronic and non-electronic systems.
Nineteen subjects (61.3%) in the aripiprazole group experienced side effects after their first dose, with the side effects experienced by four patients (21.1%) disappearing spontaneously without any management or dose reduction at the next visit.
Additional management included dose modification of study drugs.
