This is challenging for optimal patient management and continuation of therapy, and may herald early treatment failure.
This poses challenges in terms of optimal patient management and continuation of therapy, and may herald early treatment failure.
Increased awareness of potential adverse events associated with regorafenib and the implementation of proactive strategies to prevent, monitor, and manage these events early in the course of treatment will be instrumental in ensuring optimal patient management and continuation of regorafenib therapy.
With little evidence for clear environmental gains from the five refined water management plans a continuation of the current water management policy seems reasonable for the lake environment.
24 Physicians' management decisions about continuation or discontinuation of treatment were determined by compiling claims from patients' health records.
First, the method reflects continuation of management practice that is documentable, quantifiable and reviewable for a historical Reference Period (RP) comparable to the base year used in other GHG sectors.
Therefore, to avoid bias through incomplete accounting, and to ensure consistency and comparability with other GHG sectors, the full impact of policy-based changes in harvest beyond the continuation of management practices should be accounted for in the LULUCF sector.
By modelling the continuation of management practice documented historically (2000 2009), we show that these credits are mostly due to the inclusion in the reference levels of policy-assumed harvest increases that never materialized.
This approach does not include assumptions on the future impact of policies but considers fully the country-specific forest characteristics and the age-related forest dynamics, i.e. depending on the age-class legacy resulting from past management and natural disturbances, continuation of historical forest management activities may lead to future increases or decreases in the carbon sink.
As earlier noted, bringing about change at the stakeholding centers requires spending money, which is often met with resistance from the management, occasionally putting the continuation of interventions in serious jeopardy.
