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Ixabepilone-related AEs were predictable and were managed with dose modification or delay.
Transaminase elevations resolved without specific intervention and were successfully managed with dose reductions.
Side effects usually develop within 3 months of treatment and are frequently managed with dose adjustments.
Neutropenia AEs were managed with dose interruption (bosutinib, 36%; imatinib, 47%) and/or dose reduction (bosutinib, 24%; imatinib, 16%).
Grade 3/4 hematologic AEs are typically managed with dose interruptions followed by resumption of treatment at a reduced dose.
Severe AEs occurred rarely, mostly reaching grade 3 at worst, and were properly managed with dose adjustments.
Similar(37)
But that can be managed with a dose of contrite spin.
Similarly, peripheral neuropathy can be managed with appropriate dose interruptions and delays according to recognized guidelines.
The most frequently encountered toxic effects were gastrointestinal toxicities, which were managed with rest, dose reduction, or treatment discontinuation.
The manageable safety profile of ixabepilone supports its clinical utility, as adverse events can usually be managed with a dose reduction or delay, or with appropriate supportive care.
In all, 40% of the overall cohort had anaemia managed with R dose reduction and blood transfusion was used in 10%.
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