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Patients randomized to the control arm will be managed according to normal hospital rehabilitation practice.
Throughout the study cows and calves were managed according to normal practice on that farm, with farm staff diligently ensuring prompt colostrum ingestion by calves.
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Thus, once a subject is admitted after trial medication, she will be managed according to the normal protocol, ignoring the use of the trial medication.
Other than dose variation and data-gathering, patients were managed according to the Clinic's normal practices.
Anaesthesia, haemodynamics, fluid management and blood transfusion were managed according to in-house standard.
Patients were managed according to published WHO guidelines, 7, 16 including resuscitation with normal saline titrated against the clinical assessment of dehydration.
There was no management component of this study; patients were managed according to standard of care.
All patients were managed according to the local guidelines for the management of TBI.
Despite this, all episodes were managed according to BTS guidelines.
Patients were managed according to current international guidelines [37].
They must be managed according to the principle of solidarity.
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