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The DAC then notified the EGA and researchers were given access to the sequence data under the EGA's managed access system.
The challenge was to develop a managed access system that allowed rapid access to the data, while protecting the interests of participants and data generators.
We describe the development of a sustainable, easy-to-use managed access system that allowed rapid access to UK10K data, while protecting the interests of participants and data generators alike.
It was decided at the outset of the project that UK10K data should not be deposited openly on the internet and should only be accessed through a managed access system.
Many of the GWAS repositories had placed summary sequence data on the web so that researchers could see this data before applying through the managed access system to access additional datasets or to collaborate with PIs.
This has resulted in researchers now having to apply to access all data through the managed access system, which requires a formal application stating the researchers' credentials and research proposal followed by approval from the DAC.
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Another concern is that the current administrative oversight of managed access systems based on DACs may be undermining the principle of open access.
In contrast, the numbers of researchers accessing open datasets on the internet where there are no DACs is much higher than through managed access systems [ 40].
Newer datasets are being put into managed access systems whenever it is considered that managing access helps to protect research participant confidentiality; ensures that data are used within the boundaries of consent and/or other relevant approvals; and enables checks to be made to ensure that data requestors are ' bona fide' researchers.
Called managed access, the system establishes a network around a prison that detects every call and text.
Before joining the Nicholas Institute, Wilson served as Systems Librarian for NC LIVE, North Carolina's state-wide library consortium, where he redeveloped the NC LIVE website and managed access and authentication systems.
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