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Treatment was chosen if it was considered effective, user-friendly, and had acceptable, tolerable, and/or manageable side effects.
Nilotinib is generally well tolerated, with mild and manageable side effects, and is associated with some adverse events that require management to insure patient adherence to therapy and optimal treatment outcomes.
When Sofia arrived at Pharmasset, the company had already started moving away from the H.I.V.-drug development that it was initially known for, since the market had become saturated with "nucleoside" drugs that worked reliably with manageable side effects.
It has a good blood-brain-barrier penetration which results in therapeutic concentrations within the central nervous system (CNS) and confers manageable side effects.
The RA trial noted several, albeit manageable, side effects.
Toxicity was acceptable with easily manageable side effects.
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Afatinib showed a manageable side effect profile in this study.
PEP02 demonstrates moderate antitumour activity with a manageable side effect profile for metastatic, gemcitabine-refractory pancreatic cancer patients.
With the increased use of the tyrosine kinase inhibitors, several side effects began to emerge, among which was the thyroid dysfunction, which is now recognized as being an important but potentially manageable side effect of such therapy.
Overall, imatinib, dasatinib, and nilotinib are associated with manageable side effect profiles in most patients with CML; however, some patients have been found to develop intolerance to each of these TKIs 12– 12.
Sorafenib monotherapy has been shown to have a manageable side effect profile in Phase I/II/III studies (Strumberg et al, 2003, 2005; Ratain et al, 2004, 2006; Awada et al, 2005; Escudier et al, 2005).
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