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In conclusion, THALASSA data confirm that deferasirox, with appropriate dosing, effectively reduces iron overload over 2 years with a manageable safety profile providing robust evidence to assist clinicians in managing iron overload in patients with NTDT.
The clinical development program for teriflunomide demonstrated consistent efficacy and a well-characterized, manageable safety and tolerability profile.
The manageable safety profile of PD-1/PD-L1 blocking drugs identifies them as suitable for outpatient administration and the development of combinatorial therapies.
In the 2-year, phase 3 CARE-MS II study (NCT00548405), alemtuzumab had superior efficacy over subcutaneous interferon beta-1a and manageable safety over 2 years; follow-up at Year 3 showed durable efficacy of alemtuzumab.
Promising phase II activity and a manageable safety profile with ixabepilone have been seen in a wide range of tumor types, including heavily pretreated/resistant and early-stage breast cancer.
Sarilumab was generally well tolerated with a manageable safety profile.
In the current study, both agents demonstrated manageable safety profiles.
Afatinib was associated with a manageable safety profile.
Ixabepilone is associated with a generally manageable safety profile.
There was a clinically manageable safety profile in both LIC cohorts.
A manageable safety profile was seen over the 24-week study period.
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