The costs of this scheme may have been massaged by Nick Clegg to a "manageable" round figure reported as a mere £8m start-up (and £22m for the new IT system to prevent fraud).
The toxicity of CE±CAdO was mainly haematological and easily manageable as already reported (Rubie et al, 1998, 2001).
A phase I dose-escalation study of BMS-663513, an agonist anti-CD137 human monoclonal antibody, in 54 metastatic melanoma patients reported manageable toxicity (up to 15 mg/kg), with fatigue, transaminitis and neutropenia being the most common adverse events, and clinical activity that justifies its further development both as a single agent and in combination [ 64].
In a phase II study including patients with locally advanced hepatocellular carcinoma (HCC), similar common and manageable side effects were reported when continuous sunitinib treatment (25 mg/day) was combined with RTx [ 57].
Even though the primary studies reported the manageable safety profile of tofacitinib over the treatment periods [ 10, 16, 18, 19], this meta-analysis has established the significant association of tofacitinib with infections, decreased level of neutrophil and increased levels of hemoglobin, creatinine and liver enzymes (ALT and AST).
It suggests that in combination with CDDP, the total incidence of diarrhoea was increased a little; however, severe diarhoea was nearly the same and uncommon, and in any study diarrhoea was manageable, similar to those reported for UFT (Ichinose et al, 1995; Borner et al, 2002).
However, the toxicity has generally been reported to be manageable, with few deaths related to treatment toxicity.
The overall toxicity of DF was reported to be manageable: 22% of patients experienced at least one adverse event, which primarily consisted of hemorrhage (17%) and hypotension (4%).
The bevacizumab-related toxicities noted in this study were manageable and similar to those reported at lower doses of this agent (Hurwitz and Saini, 2006).
In general, Pim inhibitors demonstrate good tolerability and manageable side effects in the data reported.
