Divide your project into manageable phases and have a timeline for each phase.
The relatively recent availability of biologic therapies has considerably improved the treatment of RA, but early intervention and identification of novel drug targets are imperative to prevent the disease from progressing to the less manageable late phase (2, 3).
This prompted us to use a reductive random selection step to make the data extraction phase manageable, whilst keeping the results representative of the targeted literature, and representative of current practices in terms of psychometric validation.
In order to proceed with a manageable data extraction phase, in terms of time and available resources, whilst keeping the data representative of the literature, a sample of articles was randomly selected (Additional file 1 (AF1)), using the sample function in R 2.12.1.
This regimen was generally manageable, and a randomized phase II trial of sorafenib alone versus the combination of sorafenib with TAI of cisplatin is presently underway.
It has clinical activity with a manageable safety profile in phase 1 and 2 clinical trials, in patients with BRAF V600 -mutated metastatic melanoma [ 13].
Antagonists of survivin are also available in the clinic, producing encouraging patient responses and manageable toxicity in early-phase clinical trials [ 21].
Toxicity was much more manageable than in the European Phase II study, as a result of the weekly schedule and the lower initial dose intensity delivered.
Sorafenib monotherapy has been shown to have a manageable side effect profile in Phase I/II/III studies (Strumberg et al, 2003, 2005; Ratain et al, 2004, 2006; Awada et al, 2005; Escudier et al, 2005).
For advanced HCC patients with preserved liver function with a Child Pugh score of A, sorafenib has been reported to prolong OS compared to placebo with manageable toxicity in two pivotal phase III trials.
