PTK787, BAY 43-9006, SU11248 and ZD6474 have generally demonstrated manageable safety profiles and the dose-limiting toxicities tend to be manageable events such as gastrointestinal toxicity, fatigue and rash.
Capecitabine plus docetaxel has a manageable adverse event profile and very promising activity in metastatic oesophageal cancer, at least comparable to other doublet regimens.
The safety profile for bevacizumab plus CG in AVAiL was previously reported [ 10] and no new safety signals were observed in the current analysis, supporting the well-established and manageable adverse event profile for bevacizumab.
In conclusion, regorafenib 160 mg orally once daily in cycles of 21 days on, 7 days off treatment was tolerable, had a manageable adverse event profile and demonstrated clinical activity in heavily pretreated patients with metastatic CRC.
Indeed, patients may stop therapy after bone pain subsides or discontinue due to generally mild and usually manageable adverse events, leaving them at an increased risk of developing skeletal-related events.
Additionally, unpleasant, but usually manageable, adverse events can cause patients to discontinue therapy.
However, worsening skin may be related to many other conditions, including manageable adverse events, drug eruption or rapid exfoliative response to treatment; patients should continue on therapy when there is clinical benefit.
We have previously shown that bortezomib in combination with cyclophosphamide and dexamethasone results in a high overall response rate with manageable adverse events in patients with relapsed/refractory MM, prompting the investigation of this three-drug combination in the frontline setting [ 6].
Of note, the safety profile of bosutinib remains somewhat distinct from that of imatinib, dasatinib, and nilotinib in patients with CP CML, although all TKIs are characterized by a frequent occurrence of manageable hematologic events as well as the common need for dose modification to help manage certain toxicities [ 7– 12, 126 26].
For one, there was a clear and manageable programme of events so it was possible to see everything.
