The HsW model addresses the vastness in scope and size of task, by dividing the priority setting exercise into a succession of manageable research activities, covering all mutually exclusive and complementary interventions for the prevention and treatment of a single disease/health problem.
This combination therapy was feasible in pre-treated patients, with manageable toxicity and activity worthy of further exploration, although vigilance must be exercised in the prevention and management of neuropathy.
Larotaxel has subsequently shown good clinical activity, manageable toxicity and a favourable therapeutic index in a phase II trial conducted in 130 patients who had received prior taxane therapy for MBC [ 22].
Services for stroke and diabetes in Somerset (3 and 4) and the Wirral memory assessment service (6) struck this balance well, working with existing services and structures, and alongside providers, to focus on manageable areas of activity (table 3).
On the other hand, unimanual activities (eg, 'turning on a television') or bimanual activities manageable in several unimanual steps (eg, 'handling a stapler') were rated as less difficult for patients with asymmetric disorders, probably because these activities can be achieved by exclusively using the unaffected or less affected hand.
Keep the activities manageable, but avoid things that are overly simple or insultingly childish.
Both agents demonstrate potent activity with manageable toxicities and provide another treatment opportunity for patients with MM.
This discrete representation reduces the amount of data by several orders of magnitude, making the search space for discovering interesting activity more manageable.
Although hurricanes and bleaching events are difficult to curtail, studies have shown that mitigation of other "manageable" stressors from anthropogenic activity may help to render coral reefs more resilient in the face of climate change [20].
Preliminary antitumour activity and manageable AEs were observed.
