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A man with localized prostate cancer on ADT is at great risk for fracture, as high as 20% over five years, despite having a good overall survival outlook.
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The trial reported Wednesday involved 58 men with localized high-risk disease.
Many elderly men with localized CaP receive only hormonal therapy.
However, death rates are much higher in all men with localized high-risk disease with a 31% mortality rate [ 51].
69 As noted by the AUA, various factors must be taken into consideration when making a collective decision in the man with clinically localized CaP.
The paramount clinical dilemma in prostate cancer management is how to treat the man with clinically localized disease because the natural history is favorable overall [ 1] and the benefit from radical treatment modest [ 2].
Our research into the pathophysiology of micrometastatic dissemination and cancer recurrence has resulted in the initiation of a clinical trial for men with clinically localized and locally advanced disease.
To demonstrate the effect of 5AR inhibitors prior to localized therapy, Andriole and colleagues (2004) randomized 46 men with clinically localized prostate cancer to either dutasteride or placebo for 6 to 10 weeks prior to radical prostatectomy (Andriole et al 2004).
The appropriate therapy for men with clinically localized prostate cancer is uncertain.
To elucidate the effect of diet and comprehensive lifestyle changes on cancer risk, we are conducting a randomized, prospective clinical trial on men with clinically localized prostate cancer who have selected "watchful waiting" as primary therapy.
The recent enthusiasm for prostate cryoablation as a reasonable minimally invasive treatment option for men with clinically localized cancer is likely to result in modifications of the established surgical technique.
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