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Distributions of mammographic density phenotypes, stratified by study.
Alcohol consumption was positively associated with mammographic density phenotypes in premenopausal women.
The association between the SNPs and mammographic density phenotypes was studied with multivariable linear regression models.
Mammographic density phenotypes were assessed using a computer-assisted method (Madena).
Thus, whether there is an association between alcohol consumption and mammographic density phenotypes among premenopausal women remains unclear [ 12– 12].
Multivariable regression models were used to investigate the associations between alcohol consumption, endogenous estrogen and mammographic density phenotypes.
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Quantile-quantile (QQ) plots, per mammographic density phenotype.
Replication analysis of SNPs identified by MODE, per mammographic density phenotype.
Manhattan plots of the combined association results, per mammographic density phenotype.
These results are the consequence of the strong association of the mammographic density phenotype with breast cancer and the modest correlation in PMD between sisters.
High mammographic density (MD) is a phenotype risk marker for breast cancer.
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