Guo, W. et al. Slug and Sox9 cooperatively determine the mammary stem cell state.
"Our study establishes macrophages as important components of the mammary stem cell niche," he said.
Mohapatra, B. et al. An essential role of CBL and CBL-B ubiquitin ligases in mammary stem cell maintenance.
Guo W, Keckesova Z, Donaher JL, Shibue T, Tischler V, Reinhardt F, et al. Slug and Sox9 cooperatively determine the mammary stem cell state.
When the researchers used genetic or chemical methods to inactivate the macrophages in the mammary glands of mice, the mammary stem cell activity decreased.
Gene expression profiling of sorted GFPhigh and GFPlow cells showed that Wnt-responsive cells were enriched for a mammary stem cell transcriptional program and correlated with metastatic transcriptional signatures (Fig. 5f, g).
Their regulatory effect in cells of the immune system has been largely described42 and more recently, Cbl-b has been implicated in the maintenance of mammary stem cell phenotype involving a negative regulation of the AKT-mTOR pathway43.
Furthermore, we show that in the absence of SLUG, mammary stem cell activity necessary for tissue regeneration and cancer initiation is lost.
We describe here a mammary stem cell (MaSC) organoid-based approach for rapid generation of somatic genetically engineered mouse models (GEMMs).
Our goal was to examine the role (if any) that recently discovered mammary stem cell hierarchies play in genetic heterogeneity, DCIS initiation and aggressiveness.
The role of TGFβ signaling/SnoN in mammary stem cell regulation and breast cancer In adult mammary gland, mammary epithelial cells undergo massive proliferation and differentiation during pregnancy and lactation to produce and secrete milk.
