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In the trematode Fasciola hepatica, the initial step to successful infection of the mammalian host is the excystment of metacercariae and the invasion through the intestinal wall by the newly excysted juveniles (NEJ).
The discovery that the parasite uses lipid synthetic pathways which are different from, or absent in, the mammalian host is now driving a renewed interest in T. gondii lipid biology.
If the proportion of mutants in the seeding population is 10−4 however, the increase in proportion of respiratory droplet transmissible A/H5N1 virions in the mammalian host is small (fig. S11).
In nature, another important mammalian host is the armadillo Dasypus novemcinctus [ 22].
The parasite's survival within the mammalian host is maintained by cycles of asexual replication within red blood cells (RBC).
The vectors are ticks within the genus Rhipicephalus, mainly R. appendiculatus, and the primary mammalian host is the African Cape buffalo (Syncerus caffer).
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Pathogens constrained to survive within a mammalian host are under evolutionary pressure to acquire mechanisms that favor a chronic infection.
Second, we found that many of the same cellular pathways that are required for infection in the mammalian host are also required for infection in an insect host.
Purified recombinant TcTS enzyme or TcTS derived from trypomastigotes (similar to the infective form of the parasite present in the mammalian host) were preincubated for 30 min with the sample to be tested, and the remnant ability to transfer the sialyl residues from sialyllactose to [d-glucose-1-14C] lactose was evaluated as described above.
5 The fact that the human is the only definitive mammalian host was a factor in favor.
Transcripts that encode proteins likely to be essential for parasite development and adaptation to stress in the mammalian host are abundant in the cluster.
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