The malignant variant is the congenital infantile fibrosarcoma [1].
The levels of the different VEGF-A splice variants were significantly higher in malignant compared to normal cervical tissues.
Two mesothelioma-specific ENOX2 protein transcript variants were detected in the serum of asbestos-exposed individuals 4 10 years prior to clinical diagnosis of malignant mesothelioma (average 6.2 years).
Distinguishing malignant tissue from normal variants is a clinical challenge due to the known heterogeneity in tumors and the normal micro-environment (pathology).
Correlation between HPV16 E6 variants and malignant phenotype showed that E variants are mostly associated with high degree of differentiation, moderately and well differentiated carcinoma, whereas Af variants are more frequently found in poorly differentiated carcinoma (Table 5).
For malignant mesothelioma two ENOX2 protein transcript variants are evident; indeed multiple ENOX2 isoforms are seen in approximately half of the different types of cancer (Table 1).
Using sensitive RT-PCR-based assays, employing multiple primer sets, we find that neither mature BORIS transcripts, nor spliced variants, are commonly expressed in malignant breast cells.
This receptor or its splice variants are upregulated in many malignant tumours such as human glioma and center carcinoma.
To improve understanding of malignant hyperthermia genetics, screening of susceptible individuals only for a limited number of diagnostic RYR1 variants is not sufficient.
