Sentence examples for malignant transforming from inspiring English sources

Although most adenomas will never turn into cancer, some will eventually become malignant, transforming to stage I CRC and some may even progress into stage IV.

Codons 12 and 61 are 'hotspots' for mutations that activate their malignant transforming properties.

In c-H-ras, c-K-ras, and c-N-ras, codons 12 and 61 are 'hotspots' for mutations that activate their malignant transforming properties [1], [2], [3].

In addition to its contribution to the E6-related acquisition of malignant transforming characteristics, the PDZ-PBM interaction has a crucial role in the HPV life cycle.

Two such intermediates, FPP and GGPP modify many oncogenic proteins, including Ras and Rho GTPase for their malignant transforming activity (Jackson et al, 1990; Colditz et al, 2006).

Importantly, transgenic mice encoding E6 proteins defective for binding to PDZ domains do not develop hyperplasia or tumors [ 12], indicating the importance of this interaction for viral malignant transforming activity.

The aim of this study is to investigate the expressions of p16 and HPV16/18(E6) in oral lichen planus (OLP) and malignant transformed OLP (MT-OLP).

A plasma cell tumor is an immunoproliferative monoclonal disease of the B cell line that originates from malignant transformed plasma cells.

Our initial study reported B-SWCNT malignant transformed cells possessing an apoptotic resistant phenotype due in part to aberrant p53 signaling [13].

We found that p110α was highly detectable in the early malignant transformed human ovarian surface epithelium (Figure 2A and B).

To further confirm PIK3CA is indeed expressed in early-stage ovarian cancer, we also examined the protein product of PIK3CA gene, p110α, by immunohistochemical staining in early malignant transformed human ovarian surface epithelium.