Sentence examples for malignant transformations from inspiring English sources

Thus, in the chapter on bone tumours, the authors consider pre-existing conditions and aetiologic factors together and the account of soft tissue tumours concerns benign to malignant transformations, progression from low-grade to high-grade malignancies, and specific chromosomal translocations.

A few malignant transformations were reported in familial schwannomatosis [9].

Alterations in genes involved in cell cycle regulation and apoptosis, as tumor suppressor gene TP53, can lead to malignant transformations increasing the risk of developing cancer.

While the fields of tumor biology and experimental therapeutics have already benefited from ex vivo preclinical tissue models, these models have yet to address the reasons for malignant transformations and the emergence of chemoresistance.

Representative case studies are presented next to illustrate how chemically induced cytoskeletal changes, biomechanical responses and signals from the intracellular regions act in concert with the chemomechanical environment of the extracellular matrix and the molecular tumorigenic signaling pathways to effect malignant transformations.

Moreover the apoptosis induction system is responsible for safeguarding the system that suppresses malignant transformations.

Malignant transformation.

Malignant transformation rate.

Malignant transformation is rare [79, 80].

Rarely, malignant transformation of ameloblastoma occurs [16].

In general, schwannoma does not undergo malignant transformation [15, 16].