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Secreted MMP activity is strongly associated with malignant transformation for the cells used in this study.
The patient has been alive and well without any evidence of recurrence or malignant transformation for over 6 months.
The overexpression of each of these isoforms leads to malignant transformation (for review, see Hill and Hemmings [ 14]).
Epigenetic dysfunction is a known contributor in carcinogenesis, and is emerging as a mechanism involved in toxicant-induced malignant transformation for environmental carcinogens such as arsenicals or cadmium.
In addition, there is a tendency of malignant transformation for WHO grade II astrocytomas with a high Ki-67 level or TP53 expression in initial samples.
The aim of this study is to investigate the roles of cell-cycle-regulators p53, p21, p27, proliferation marker Ki-67, p16, PCNA, and innate immune material PLUNC in recurrence and malignant transformation for sinonasal IPs.
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These two types of variation are thought to be implicated in malignant transformations for many (if not all) types of solid tumors.
Somatic mutations are more common, and might account for malignant transformation of sporadic tumors.
This case report highlights the imaging findings for malignant transformation of intestinal endometriosis.
We aimed at investigating the lifestyle-related risk factors for malignant transformation of OSF.
This study was done to evaluate/investigate the natural history of simple ovarian cysts in postmenopausal women and to determine the risk for malignant transformation of these cysts.
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CEO of Professional Science Editing for Scientists @ prosciediting.com