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The polyomaviruses produce malignant transformation of infected cells.
The factors underlying the malignant transformation of MGUS are unknown.
Overexpression induces malignant transformation and drives metastatic growth.
Malignant transformation and metastasis of IPEH has not been reported.
Recurrence and possible malignant transformation are consequences of incomplete excision.
Three dimensional cultures: a tool to study normal acinar architecture vs. malignant transformation of breast cells.
Rutnam, Z. J. & Yang, B. B. The involvement of microRNAs in malignant transformation.
Wurm, M. et al. Ectopic expression of HOXC6 blocks myeloid differentiation and predisposes to malignant transformation.
Myriad genetic and epigenetic alterations are required to drive normal cells toward malignant transformation.
Under some circumstances these genes may also induce malignant transformation of normal cells.
Miura, M. et al. Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation.
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