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In summary, by coupling the systematic genomic analysis of purified cancer cells in distinct malignant states from mouse models with extensive human validation, we uncovered several key regulators of metastatic ability, including an actionable pro-metastatic CD109-Jak-Stat3 CD109-Jak-Stat3 CD109-Jak-Stat3
Differential expression between normal and malignant states may provide one method for prioritization of candidates moving forward.
These 3 cell lines differ in their Ig VDJ sequences, malignant states, and metastatic capabilities.
In general, cancers arise from one abnormal cell that goes through multiple transformations from normal to malignant states.
Finally, senescent and malignant states share common features of altered chromatin structure, epigenetic changes and DNA damage.
EMT is involved in both embryonic development and progression of carcinoma toward dedifferentiated and more malignant states [ 1].
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For 50 years, Big Brother was an unambiguous symbol of malignant state power, totalitarianism's all-seeing eye.
The cellular transition from normal to malignant state is linked to deregulated gene expression.
Santagata, S. et al. Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state.
den Hollander, J. et al. Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state.
Santagata S, Mendillo ML, Tang YC, Subramanian A, Perley CC, Roche SP et al. Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state.
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