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In the fourth column the same results are reported for the malignant side.
A significant enlargement of the IMA on the malignant side occurs in most patients.
In the presence of malignancy this study showed a significant enlargement in the cross-sectional area of the IMA and IMV on the malignant side.
The aim of this study was to investigate whether a significant difference exists between the cross-sectional area of IMA and IMV between the healthy and the malignant side in unilateral breast cancer patients.
The measured mean cross-sectional area of the IMA in the second ICS was 4.63 mm2 on the healthy side (range 2.01 13.22) and 5.94 mm2 on the malignant side (2.06 13.53).
In the malignancy group, the results of reader 1 showed a significant difference in the cross-sectional area of the IMA and IMV in the second as well as in the third ICS between the healthy and malignant side (see Fig. 3 for an example).
Similar(52)
Thus, the therapeutic potential of HDAC inhibitors in various malignancies including that of exocrine pancreas may be enhanced when used in combination with small molecules that counteract their pro-malignant side effects such as an increase in POLR3-mediated transcripts.
It will be enticing to test if ML-60218 used in combination with HDAC inhibitors can augment the growth-suppressive effect of HDAC inhibitors in tumors including that of exocrine pancreas, by counteracting their pro-malignant side effect of stimulating POLR3-mediated transcription.
These findings demonstrate that chemically targeting developmental regulators of exocrine pancreas can be translated into an approach with potential impact on therapeutic response in pancreatic cancer, and suggest that counteracting the pro-malignant side effect of HDAC inhibitors can enhance their anti-tumor activity.
We have compared, for the first time, the stem/progenitor markers of normal and malignant breasts side-by-side.
Although ROS-inducing agents like ATO have shown great potentials in the treatment of malignant cells, the side effects remain to be fully evaluated [9].
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