Nine non-cancer samples that clustered with cancer samples included 5 pre-malignant lesions (1 adenomatous polyp and 4 intestinal metaplasia).
Melanoma samples included as positive controls showed intense S100B expression within the malignant cells (data not shown).
The haematoxylin-eosin staining revealed that all ovarian samples included in this study were healthy and did not possess any malignant tissue.
Indeterminate samples included a pattern of follicular or Hurthle cell neoplasm or aspects of atypia suggestive, but not conclusive of the presence of a malignant neoplasm [ 14].
Truncated AR-Vs lacking the LBD and proposed to be constitutively active receptors have been detected in PC cell lines as well as in clinical samples, including benign, malignant and metastatic tissue, as results from alternative splicing or non-sense mutations of the human AR gene [9], [10], [11], [12], [13], [14], [15], [16], [17].
The human data set consists of 129 samples, including 68 malignant tumors and 61 matched adjacent normal samples.
A total of 130 mammary neoplasm samples (including benign, malignant and lymph node metastases specimens) were selected from the archives of the Veterinary Pathology Department (FCAV/Unesp - Jaboticabal).
The method has been shown to be sensitive to select malignant cells from small tissue samples, including patients with Stage M0 BC.
This study is the first comprehensive analysis of the expression of the entire MMP and TIMP families in a large series of human prostate tissue samples, including both malignant (adenocarcinomatous) and nonmalignant (hyperplastic) tissue.
We have developed an alternative assay method for DHODH activity in biological samples, including cultured HeLa cells and fibroblasts, and normal and malignant human stomach tissues.
