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A key question that arises from the observed similarities between genetic changes in hPSCs and cancer cells is whether adapted hPSCs exhibit similar malignant properties to cancer.
Re-expression of molecules involved in embryogenesis can confer malignant properties to tumour cells.
We overexpressed INPP1 in the ovarian cancer cells OVCAR3 and SKOV3 and melanoma cancer cells MUM2C but did not observe increases in cell migration, invasiveness, proliferation, or survival, indicating that INPP1 alone may not be sufficient to confer malignant properties to cancer cells (data not shown).
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Hsp27 belongs to a small HSP family and has been found to contribute to the malignant properties of cancer cells, including increased tumorigenicity, treatment resistance and apoptosis inhibition [ 3].
We next determined whether KLF4/5 contributed to malignant properties independently of lapatinib exposure.
Moreover, whether elevated DDX5 contributes to other malignant properties of NSCLC cells, such as EMT and metastasis, also remains to be determined.
Cancer cells are suspected to hijack the Keap1-Nrf2 system as a means to acquire malignant properties.
New studies that aim to target both genetic and epigenetic alterations (noncoding microRNA) underlying malignant properties of tumor cells and to specifically attack tumor cells using cell surface markers overexpressed in tumor tissue are emerging.
C6 cells were found to produce only a small amount of GFAP due to their malignant properties (Messens and Slegers, 1992).
The molecular mechanisms that give rise to the malignant properties of SP cells are not clear.
Further studies are required to understand how these ligands, which share the same receptor on cancer cells, are orchestrated to induce malignant properties in pancreatic cancer.
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