Hsp90 plays a key role in regulating the physiology of cells exposed to environmental stress and in maintaining the malignant phenotype of tumor cells.
During latent infection, EBV continuously expresses a number of viral genes which are essential for cell transformation and maintenance of the malignant phenotype of EBV-related tumors.
These data suggest an association of serum EPCA with the malignant phenotype of prostatic carcinoma.
Additional experiments were undertaken to ascertain if miR-31 enhances the malignant phenotype of lung cancer cells.
However, our microarray analysis suggests that COX-2 is a key molecule in the malignant phenotype of mesenchymal tumor cells.
Collectively, these experiments strongly suggest that miR-31 enhances the malignant phenotype of human lung cancer cells.
Epithelial cell transforming sequence 2 (ECT2) is a guanine nucleotide exchange factor for Rho family GTPase, which has been implicated in the malignant phenotype of human cancers.
GLI1 expression is important to support the malignant phenotype of ESFT cell lines whether inhibited by shRNA, endogenous regulators, or by pharmacologic agents.
The DMs in the micronuclei are active in transcription when surrounded by the nuclear lamina [7] and can still contribute to the malignant phenotype of cells.
Moreover, inhibition of PDK1 expression has been shown to decrease lactate levels and HIF-1α expression and reduce the malignant phenotype of cancer cells [52].
SPARC shRNA expression enhanced the malignant phenotype of PDAC cells.
