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Malignant pathologies were identified in eight cases (endometrial cancer n = 3, cervical adenocarcinoma n = 1, ovarian cancer n = 4).
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Discrimination of benign from malignant pathologies was highly specific (93%) and reasonably sensitive (79%).
The NPV (89%) between benign and malignant pathologies was higher than the PPV (86%).
Although its contribution to benign and some malignant pathologies is recognised, it has been largely neglected in molecular and biological studies.
Although the contribution of myoepithelial cells to benign and some malignant pathologies is recognized, this cell type has been largely neglected in molecular and biological studies.
Discrimination between benign and malignant pathologies was more accurate (88%) because these distribution sizes were more equally represented in the classifier training set.
Discrimination of benign from malignant pathologies was highly specific (93%) and reasonably sensitive (79%), although sensitivity was limited in underrepresented pathologies like DCIS and residual invasive cancers after neoadjuvant chemotherapy (61% to 66%).
While TIL represent a fascinating therapeutic approach in numerous malignant pathologies, there is few report concerning adult bone-associated tumors including osteosarcoma.
Underlying pathologies were classified into two groups: malignant (carcinomas or lymphomas) and benign (all other causes).
In summary, the ADERS hypothesis states that malignant transformation (along with some other pathologies) is facilitated by epigenetically mediated extreme adaptation to accumulated stress.
The pathologies are achingly real.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com