Sentence examples for malignant expansion of from inspiring English sources
These results are consistent with the previously suggested notion that many HCC's derive from the malignant expansion of less mature hepatocytes or oval cells [23].
Therefore, aberrant responses to infection(s) could lead to leukemia through the abnormal proliferation of immune cells or a failure to curb the malignant expansion of an abnormal immune cell.
The tyrosine kinase activity of fusion protein P210bcr/abl leads to uncontrolled cell proliferation with suppressed apoptosis and then results in the malignant expansion of multipotential hematopoietic stem cells in bone marrow [ 5].
Conditional activation of PyMT in β cells led to irreversible non-malignant expansion of the β cell population, regardless of the developmental stage at which it was expressed.
Transformation of MLL-AF9 fusion gene into mouse ES cells demonstrated that non-malignant expansion of myeloid precursors is the first stage of MLL-AF9-mediated leukemia followed by accumulation of malignant cells in bone marrow and other tissue [4].
Comparing these frequencies with those observed ex vivo in follow-up studies allows to monitor any clonal imbalance and possibly predict adverse events caused by pre-malignant expansion of cells carrying gene deregulating insertions.
Likewise, insertional transactivation of myeloproliferative genes like MDS1/EVI1, PRDM16 or SETBP1 has resulted in clonal dominance and malignant expansion in some CGD patients.
Leukemias and lymphomas represent malignant, clonal expansions of white blood cell populations.
Precursor B acute lymphoblastic leukemia (BCP-ALL), the most common childhood malignancy, arises from an expansion of malignant B cell precursors in the bone marrow.
Multiple myeloma is a hematological malignancy associated with clonal expansion of malignant plasma cells within the bone marrow.
Multiple myeloma (MM), a common hematological malignancy arising from clonal expansion of malignant plasma cells, vividly highlights this notion.
