Sentence examples for malignant expansion from inspiring English sources
These results are consistent with the previously suggested notion that many HCC's derive from the malignant expansion of less mature hepatocytes or oval cells [23].
Likewise, insertional transactivation of myeloproliferative genes like MDS1/EVI1, PRDM16 or SETBP1 has resulted in clonal dominance and malignant expansion in some CGD patients.
Therefore, aberrant responses to infection(s) could lead to leukemia through the abnormal proliferation of immune cells or a failure to curb the malignant expansion of an abnormal immune cell.
The tyrosine kinase activity of fusion protein P210bcr/abl leads to uncontrolled cell proliferation with suppressed apoptosis and then results in the malignant expansion of multipotential hematopoietic stem cells in bone marrow [ 5].
On one hand, there is clear evidence that COX-2 is an important player even in advanced tumours, where a constellation of other cellular components, such as activated oncogenes and inactivated tumour suppressors, has usurped growth control and drives the malignant expansion.
Conditional activation of PyMT in β cells led to irreversible non-malignant expansion of the β cell population, regardless of the developmental stage at which it was expressed.
Transformation of MLL-AF9 fusion gene into mouse ES cells demonstrated that non-malignant expansion of myeloid precursors is the first stage of MLL-AF9-mediated leukemia followed by accumulation of malignant cells in bone marrow and other tissue [4].
Comparing these frequencies with those observed ex vivo in follow-up studies allows to monitor any clonal imbalance and possibly predict adverse events caused by pre-malignant expansion of cells carrying gene deregulating insertions.
Thus far, these results suggest that Pho-s impaired the malignant clone expansion and proliferation.
Non-Hodgkin's lymphoma (NHL) represents a large heterogeneous group of B-cell and T-cell lymphomas characterized by uncontrolled malignant clonal expansion.
Synthetic phosphoethanolamine has anti-leukaemic effects in an APL model by inhibiting malignant clone expansion, suggesting that it is an interesting compound for leukaemia treatment.
