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A differential modulating effect for BRCA1 mRNA expression was also observed in tumor cells isolated from malignant effusions of non-small-cell lung cancer and gastric cancer patients, whose BRCA1 mRNA levels correlated negatively with cisplatin sensitivity and positively with docetaxel sensitivity [33].
Primary tumour cells were collected from peritoneal malignant effusions of patients with ovarian cancer.
VEGF-A also induces vessel permeability and the accumulation of malignant effusions of ascites in ovarian cancer [ 9].
In our previous study in tumour cells isolated from malignant effusions of gastric cancer patients, we observed a similar effect of BRCA1 expression (Wang et al, 2008).
To identify OCAFs of OVCA, various peptide growth factors and cytokines have been detected in the malignant effusions of OVCA patients (Westermann et al, 1997).
Compared with primary tumors and solid metastases, reduced CRT expression was observed in malignant effusions of high-grade ovarian carcinoma along disease progression [ 56].
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We recently established a new human breast cancer cell line, designated KPL-3C, from the malignant effusion of a breast cancer patient with HHM.
We recently established a new human breast cell line, designated KPL-1, which was derived from the malignant effusion of a patient with breast cancer.
KPL-1 is a human breast carcinoma cell line that was established from the malignant effusion of a breast cancer patient [ 22].
The remainder included one each of the following: Hodgkin's lymphoma, chronic lymphoid leukaemia, osteosarcoma, Ewing's sarcoma, gastric cancer, renal cancer, oesophageal cancer and a malignant effusion of undetermined primary source.
The use of short-term cultures of malignant effusions as the source of cells for use as target cells in cytotoxicity tests and in chemotherapy assays is disscussed.
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