Fate tragedy, also called fate drama German, Schicksalstragödie, a type of play especially popular in early 19th-century Germany in which a malignant destiny drives the protagonist to commit a horrible crime, often unsuspectingly.
These attributes are considered hallmarks of tumor cells and are characterized as being an integral component of a transition from a relatively quiescent to a "malignant" phenotype, driven by a local increase in ECM rigidity [16].
We conclude that, unexpectedly, the lack of NG2 does not prevent the generation of malignant gliomas driven by PDGF-B overexpression.
This suggests that overexpression of ILK may be required, not only for the initiation of premalignant changes, but also for the maintenance of the malignant phenotypes driven by Wnt signaling.
Two recent studies of lymphoma and breast cancer have identified components of the spliceosome — the core splicing machinery — that are essential for malignant transformation driven by the transcription factor MYC.
On the other hand, the development of an envelope of small scale pseudopalisades may play a relevant role in the global migratory dynamics and invasion of these malignant gliomas driven by vaso-occlusive events occurring at the small cellular scale, leading to the distinctive GBM feature of showing significant necrotic areas, as observed in clinical imaging such as the on exhibited in Fig. 1(B).
Does apoptosis drive malignant transformation in pre-malignant conditions such as therapy-related myelodysplastic syndromes or congenital bone marrow failure syndromes?
The mutations cause a hereditary thrombocytosis, but haematopoiesis is polyclonal and individuals do not develop haematological malignancies or solid tumours, suggesting that JAK/STAT activation alone does not drive malignant disease.
Oncogenic KRAS can activate numerous effector pathways to drive malignant progression.
Cancer is characterized by multiple genetic and epigenetic alterations that drive malignant cell proliferation and confer chemoresistance.
