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VELscope™ is a device designed to help detect potentially malignant disorders of the oral mucosa at an early stage using direct tissue autofluorescence.
The presence of YB-1/p18 in plasma samples may indicate malignant disorders of different origin.
Oral leukoplakia (OLK) is one of the most common malignant disorders of the oral mucosa.
The myelodysplastic syndromes (MDS) are a spectrum of malignant disorders of blood cell production, which affects over 250 000 people worldwide, with the potential to develop into acute leukaemia.
The transformation rate of other potentially malignant disorders of the oral and oropharyngeal mucosa is harder to quantify, ranging from 0.13% to 2.2% for all potentially malignant disorders combined (Napier and Speight, 2008).
Gestational trophoblastic neoplasia (GTN) encompasses a spectrum of disorders from the premalignant conditions of complete and partial hydatidiform moles (CHM or PHM) to the malignant disorders of invasive mole, choriocarcinoma, and placental site trophoblastic tumour (PSTT).
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Acute lymphoblastic leukemia (ALL) is a malignant disorder of lymphoid progenitor cells and characterized by chromosomal abnormalities, which occurs at all ages but with peak prevalence between the ages of 2 and 5 years [18].
Multiple myeloma (MM) is a malignant disorder of plasma cells arising from a clinically benign state known as monoclonal gammopathy of undetermined significance (MGUS).
Oral leukoplakia (OL) is defined as "A white plaque of questionable risk having excluded (other) known diseases or disorders that carry no increased risk for cancer", which is the best-known potentially malignant disorder of the oral mucosa [ 3, 4].
Multiple myeloma is a malignant disorder of bone marrow plasma cells that accounts for approximately 13% of all haematological cancers and 1% of all cancers (Terpos and Rahemtulla, 2005; Kyle and Rajkumar, 2008).
Furthermore, other tumours and selected cases of non-malignant disorders of the stomach may require partial or total gastrectomy.
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