Sentence examples for malignant conversion of from inspiring English sources

Approximately 15 20% of global cancer incidence is causally linked to viral infection, yet the low incidence of cancers in healthy infected individuals suggests that malignant conversion of virus-infected cells occurs after a long period as a result of additional genetic modifications.

Compared with many other cell systems, malignant conversion of these cells occurs with relative ease.

The studies suggest Smad3 does not alter proliferation, but prevents malignant conversion of papillomas formed by engraftment onto nude mice.

The loss of nuclear IKKα contributes to malignant conversion of keratinocytes into less differentiated and proliferative carcinoma cells.

Also, recent reports have shown that cancer stromal alterations precede the malignant conversion of tumour cells [ 31].

Therefore, these cases were expected to provide unique opportunities to demonstrate the existence of stochastic radiation signatures associated with malignant conversion of thyroid follicular cells.

Recently, Myc has been suggested to be at the center of human liver tumor malignant conversion, on the basis of genome-wide gene expression profiling (Kaposi-Novak et al., 2009), but this conclusion still lacks experimental confirmation and thus an in vivo animal model is highly desired.

In contrast, an interesting feature of our model is that when papillomas do arise in EPI-/ mice they have a higher frequency of malignant conversion to SCCs than WT papillomas.

Given the high risk of malignant conversion, surgical resection of the cyst, especially the extrahepatic bile duct, has been recommended for type IV CCs [23, 24].

Therefore, HPV infection alone was considered insufficient for the malignant conversion suggesting role of other genetic changes in the development of CC.

Polyp size has been known to correlate with malignant conversion, with rates of HGD increasing significantly for polyps >20 mm [ 7, 27].